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With a research team, they study the signaling patterns in the hippocampus and how they changed under stress. In this part of the brain, it's been associated with mood disorders, partly due to its sensitivity to full-on stress, and it's also involved in emotional behavior. Any disruption to this part of the brain can impact how it processes stress, which might set the stage for depression and anxiety. Researchers in Shelton, Washington, male mice prone to developing depressive and depression and anxiety-like behavior after long periods of stress have levels of ATP. They also produce less protein needed for ATP release, and this protein was Connexin 43, just dropping.