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This investigation conducted from 2015 to 2020 was the first to show change in the blood grains in the brain and microgravity. There's an impairment in intergenerational pressure, PI-90, and having a role of those fluid shifts and the resulting increase in brain fluid pressure might play a role in the development of the shift. Research studies about the rise in measures including pit of body and with and without dilation, imaging of the retina, associated blood vessels and nerves, and imaging to measure the thickness of the breathable structures and the MRI imaging of the eye and optic nerve.