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And just to wrap up on this one, later, humans migrated to the Americas where natural selection favored the spread of this borrowed MUC19. No one knows why the Denisovan variant became so common in North and South America, but in other parts of the world. The first people who lived in America likely encountered the conditions, including new kinds of food and diseases, so Denisovan DNA may have given them additional tools to help with the challenges that come from contracting these new pathogens and some of the new foods.