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So, back to my first point, the polycyclic aromatic hydrocarbons, those are typically found in the soot as well as the heavy metals and that's what is the VOCs as well, but it's the sit and heavy metals that really push up the PM2.5 data. It's not good, heavy metals and bodies for example, those generate reactive oxygen species, so ROSs and reactive nitrogen species, RNS, and those can actually induce severe oxidative stresses, they can deplete cellular antioxidants and they can bind to DNA and nuclear proteins and this can actually structurally damage cells and in some cases if you have enough exposure can cause death, but when it damages the cells it can cause cell death depending on the amount of damage to the cells and of course,